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Imeglimin protects against acute kidney injury caused by transient ischemia

Muramatsu H, Yoshida N, Suzuki K, Ueda K, Kawarazaki W, Marumo T

Biochem Biophys Res Commun 807, 153437, 2026

Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes

Marumo T, Yoshida N, Inoue N, Yamanouchi M, Ubara Y, Urakami S, Fujii T, Takazawa Y, Ohashi K, Kawarazaki W, Nishimoto M, Ayuzawa N, Hirohama D, Nagae G, Fujimoto M, Arai E, Kanai Y, Hoshino J, Fujita T

Am J Physiol Renal Physiol 327, F397-F411, 2024

Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney

Takenaka T, Hasan A, Marumo T, Inoue T, Miyazaki T, Suzuki H, Kurosaki Y, Ishii N, Nishiyama A, Hayashi M

Kidney Blood Press Res . 48 (1), 326-337, 2023

Rac1 deficiency impairs postnatal development of the renal papilla

Ayuzawa N, Nishimoto M, Kawarazaki W, Oba S, Marumo T, Aiba A, Fujita T

Sci Rep 12 (1), 1-14, 2022

Klotho supplementation attenuates blood pressure and albuminuria in murine model of IgA nephropathy

Takenaka T, Hasan A, Marumo T, Kobori H, Inoue T, Miyazaki T, Suzuki H, Nishiyama A, Ishii N, Hayashi M

J Hypertens 39 (8), 1567-1576, 2021

Activation of Rac1-mineralocorticoid receptor pathway contributes to renal injury in salt-loaded db/db mice

Hirohama D, Nishimoto M, Ayuzawa N, Kawarazaki W, Fujii W, Oba S, Shibata S, Marumo T, Fujita T

Hypertension 78 (1), 82-93, 2021

Methylation pattern of urinary DNA as a marker of kidney function decline in diabetes

Takeshi Marumo, Junichi Hoshino, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Masayuki Yamanouchi, Yoshifumi Ubara, Toshikazu Okaneya, Takeshi Fujii, Kazunari Yuki, Yoshihito Atsumi, Atsuhisa Sato, Eri Arai, Yae Kanai, Tatsuo Shimosawa, Toshiro Fujita

BMJ Open Diabetes Res Care 8 (1), e001501, 2020

Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency

Wakako Kawarazaki, Risuke Mizuno, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Kohei Ueda, Fumiko Kawakami-Mori, Shigeyoshi Oba, Takeshi Marumo, Toshiro Fujita

J Clin Invest 130 (8), 4152-4166, 2020

PGI 2 analog attenuates salt-induced renal injury through the inhibition of inflammation and rac1-MR activation

Daigoro Hirohama, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita

International Journal of Molecular Sciences 21 (12), 4433, 2020

Two mineralocorticoid receptor–mediated mechanisms of pendrin activation in distal nephrons

Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Kohei Ueda, Daigoro Hirohama, Wakako Kawarazaki, Tatsuo Shimosawa, Takeshi Marumo, Toshiro Fujita

Journal of the American Society of Nephrology 31 (4), 748-764, 2020

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