Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes
Marumo T, Yoshida N, Inoue N, Yamanouchi M, Ubara Y, Urakami S, Fujii T, Takazawa Y, Ohashi K, Kawarazaki W, Nishimoto M, Ayuzawa N, Hirohama D, Nagae G, Fujimoto M, Arai E, Kanai Y, Hoshino J, Fujita T
Am J Physiol Renal Physiol 327, F397-F411, 2024
Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney
Tsuneo Takenaka, Arif Hasan, Takeshi Marumo, Tsutomu Inoue, Takashi Miyazaki, Hiromichi Suzuki, Yoshifumi Kurosaki, Naohito Ishii, Akira Nishiyama, Matsuhiko Hayashi
Kidney Blood Press Res . 48 (1), 326-337, 2023
Rac1 deficiency impairs postnatal development of the renal papilla
Ayuzawa N, Nishimoto M, Kawarazaki W, Oba S, Marumo T, Aiba A, Fujita T
Sci Rep 12 (1), 1-14, 2022
Klotho supplementation attenuates blood pressure and albuminuria in murine model of IgA nephropathy
Takenaka T, Hasan A, Marumo T, Kobori H, Inoue T, Miyazaki T, Suzuki H, Nishiyama A, Ishii N, Hayashi M
J Hypertens 39 (8), 1567-1576, 2021
Activation of Rac1-mineralocorticoid receptor pathway contributes to renal injury in salt-loaded db/db mice
Hirohama D, Nishimoto M, Ayuzawa N, Kawarazaki W, Fujii W, Oba S, Shibata S, Marumo T, Fujita T
Hypertension 78 (1), 82-93, 2021
Methylation pattern of urinary DNA as a marker of kidney function decline in diabetes
Takeshi Marumo, Junichi Hoshino, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Masayuki Yamanouchi, Yoshifumi Ubara, Toshikazu Okaneya, Takeshi Fujii, Kazunari Yuki, Yoshihito Atsumi, Atsuhisa Sato, Eri Arai, Yae Kanai, Tatsuo Shimosawa, Toshiro Fujita
BMJ Open Diabetes Res Care 8 (1), e001501, 2020
Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency
Wakako Kawarazaki, Risuke Mizuno, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Kohei Ueda, Fumiko Kawakami-Mori, Shigeyoshi Oba, Takeshi Marumo, Toshiro Fujita
J Clin Invest 130 (8), 4152-4166, 2020
PGI 2 analog attenuates salt-induced renal injury through the inhibition of inflammation and rac1-MR activation
Daigoro Hirohama, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
International Journal of Molecular Sciences 21 (12), 4433, 2020
Two mineralocorticoid receptor–mediated mechanisms of pendrin activation in distal nephrons
Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Kohei Ueda, Daigoro Hirohama, Wakako Kawarazaki, Tatsuo Shimosawa, Takeshi Marumo, Toshiro Fujita
Journal of the American Society of Nephrology 31 (4), 748-764, 2020
Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study
Mitsuhiro Nishimoto, Hiroshi Ohtsu, Takeshi Marumo, Wakako Kawarazaki, Nobuhiro Ayuzawa, Kohei Ueda, Daigoro Hirohama, Fumiko Kawakami-Mori, Shigeru Shibata, Miki Nagase, Masashi Isshiki, Shigeyoshi Oba, Tatsuo Shimosawa, Toshiro Fujita
Hypertension Research 42 (4), 514-521, 2019
